I have searched visceral pleural invasion and Stage III but I can't find answers. I am sorry if I have missed something. My husband who is 71 and a never smoker (but exposed to asbestos) had a left pneumonectomy in October for adenocarcenoma 7.2cm (pT3N1M0). Only yesterday did we think to ask for a copy of the pathology report. It mentions 'completely excised', but also says there was visceral pleural invasion. Neither the surgeon nor the oncologist has ever mentioned this.

So sadly mom's new tumors do not have mutations and her Dr. has left the decision of what treatment to try next up to her. He would like her to do Taxol but the dreaded hair falling out seems to be pretty significant to my mom. The other options are Taxotere or Navelbine.

I'm struggling to find out what the 2nd line can or may offer her. Obviously the more aggressive seems like a good path but at what cost? How much can it help?

My husband was diagnosed Stg IV NSCLC December 2013. Poorly defined adenocarcinoma posive EGFR. Progressed to adrenal gland, lymph node, shoulder, spine, hips. Tarceva was pretty rough at 150 but at 100 it was tolerable. Remarkable response on tarceva. Eight good months before progression. First to bones, then adrenal gland. Biospy showed T790 negatve. Started chemo Jan 2015. Stopped Tarceva two days before starting chemo. Carbo, Alitma, Avastan. Chemo side effects extremely harsh. And symptons continued to progress, with pain throughout the body.

My brother, 50 years old, has Stage IV NSCLC (adeno);diagnosed September 2013; inoperable; no relevant mutations. He had undergone radiation to lung and several rounds of chemo (Carboplatin, Taxotere, Cisplatin, Gemzar). He also had surgery to remove one brain met (January 2014) and one kidney (May 2014)... CT scan in December showed no mets outside lung and lymph nodes....

Hello,

I see this forum very helpful. I will appreciate if doctors can guide us here.

My mother is age 62, never smoked vegeterian diet. She is diagnosed with NSCLC Lung cancer stage 4, metastized to liver, bronchus and adrinal.

The biopsy report says:

Poorly differentiated non small cell carcinoma.
On immunohistochemistry, tumour cells are positive for CK7 and TTF-1 and very focally positive for p63.

First, thank you GRACE for placing the yellow banner on the top of the page asking for help!

I didn't realize that only 0.1% of site visitors donate to GRACE. It is a god send organization when I learned the love of my wife has lung cancer. The lung cancer survival statistic is abysmal just like donation to GRACE.

Good afternoon,

it has been announced that trials are set to start in uk, does anyone know how successful this treatment is for NSCLC

http://www.theguardian.com/society/2015/mar/06/lung-cancer-stem-cell-th…

Hi there

My dad (66 years) was recently diagnosed with stage 4 pleomorphic carcinoma. The pathology report for the biopsy shows positive for TTF-1, Napsin A, CK7 and negative for CK20 and weakly positive for CK5/6. It is also negative for EGFR and ALK. So my oncologist recommended chemo with Alimta (Pemetrexed) and Carboplatin (Paraplatin). I did some reading and learned that this is a rare and aggressive cancer that is less researched and difficult to treat.