Are you showing resistance to Clovis (CO-1686)? What is your treatment now?
What are the avail options out there? I appreciate any advice anyone has.
Has anyone gone back to Tarceva? What about Afatinib?
My dad, Dx'ed with stage IV NSCLC, completed 5 cycles of Clovis (CO-1686 500mg) as a second line treatment, just had a scan today (7/9/15), and the results were not great. His first line treatment was with Tarceva + chemo (Alimta+Carbo, then Alimta for maintenance).
There's cancer progression, with the main hilar mass in his RUL, measured at 32mm on 5/28/15 (after completing 3 cycles and stable in 2 previous scans while on the trial), and now 39mm today. His Onc at Cedars-Sinai is stopping the trial and is now planning the 3rd line treatment, with the following options:
1. Standard: (a) Docetaxel (taxotere) chemo
2. Phase-1 clinical trials:
I have zero knowledge about these 2 trials, so I'll be researching these. But I would love to hear if anyone has any advice for me.
I am also considering getting a second opinion at a different facility, like City of Hope. Can you recommend an oncologist?
We discussed with his Onc two other trials, but he didn't qualify:
3. Peregrine, a form of immunotherapy, a randomize trial with 50% patients on Docetaxel (taxotere) + placebo and the other 50% on Docetaxel (taxotere) + a drug called Bavituximab (attacks blood vessels and activates the immune system). Do not qualify because it's only for patients who just had std chemo, and is a 2nd line treatment, and also, more importantly since the drug attacks the blood vessels, the main tumor is "very close" to one.
4. Anti-PDL 1? but it's for first line treatment...patients with no prior therapy.
Thank you and take care,