Dear Doctors and Moderators,
I have been on tarceva for 9 months and after progression and high toxicity moved to Tagrisso. Blood biopsy showed same l858r mutation, but no t790m one. My question is: if I progressed on osimertinib but keeping same original mutation, can I try afatinib? Or Tagrisso plus afatinib combo? Or Tagrisso plus avastin? Retry tarceva plus Tagrisso combo?
Thank you very much for your assistance.