Wondering if anyone has info on compatibility of berberine with Tarceva. I called Genentech but they didn’t know. I am taking it because it has similar properties to metformin but less side effects as it lowers blood glucose levels and other benefits.
Reply # - August 30, 2018, 11:59 AM
These sources indicate an interaction.
"Berberine is known to inhibit CYP2D6, CYP2C9, and CYP3A4, which can lead to a host of drug interactions, some of which can be serious..."
"Analyses in vitro using human liver microsomes and recombinant enzymes showed that erlotinib was metabolized primarily by CYP3A4, with a secondary contribution from CYP1A2."
Have you discussed this with your oncologist?
Reply # - September 4, 2018, 09:45 AM
So it inhibits Tarceva or potentiates it?
Reply # - September 4, 2018, 10:50 AM
I posted a reply at inspire: https://www.inspire.com/groups/american-lung-association-lung-cancer-su…