Berberine and Tarceva - 1295164


Wondering if anyone has info on compatibility of berberine with Tarceva. I called Genentech but they didn’t know. I am taking it because it has similar properties to metformin but less side effects as it lowers blood glucose levels and other benefits.


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Hi Ibook52,

These sources indicate an interaction.

"Berberine is known to inhibit CYP2D6, CYP2C9, and CYP3A4, which can lead to a host of drug interactions, some of which can be serious..."

"Analyses in vitro using human liver microsomes and recombinant enzymes showed that erlotinib was metabolized primarily by CYP3A4, with a secondary contribution from CYP1A2."…

Have you discussed this with your oncologist?