My dad had a 3rd biopsy sent to a lab for next generation screening in order to identify genetic markers for targeted therapies. They received the sample in a paraffin block. We were just told that they needed it to be at least 20% malignant cells, and my dad's sample contained less than 10% malignant cells.
First time it was done with a needle aspiration and the next 2 times it was done through the esophagus, and each time we were told that the sample was not large enough. He is thinking of having a 4th biopsy. Is this dangerous? Is there a better way to find these genetic bio markers?
The 2nd biopsy did have negative results for EGFR, KRAS, and ALK. Now we wanted to test for ROS-1 and any other potential bio markers.
Dad has adenocarcinoma which responded to carboplatin, alimta and abraxane but had a severe allergic reaction to carboplatin. He also developed peripheral edema from alimta and peripheral neuropathy with abraxane, so we're anxious to find a better therapy.
Thanks in advance for any input.