Egg freezing (Oocyte cryopreservation) during treatment in Tagrisso

Thu, 11/12/2020 - 12:05

Dear All good day,

I am Serpil, ı have lung cancer (adenocarcinoma) sinse 2017. First year i used Tarceva and it helps to remove 60-70% of cancer cells. Now I am using Targrisso within two years. The cancer cells seems passive and my treatment still continue. I went to the Obstetrician due to delay of the my period and ovarian reserve was found (AMH) 0,92 ng/ml. Is it possible to freeze my eggs. Did you perform egg freezing operation while treatment under Tagrisso?

Thank in advance 

Age: 32 / Sex: Woman / Adenocarcinoma 


JanineT Forum …

Hi Serpil,


Welcome to Grace!  It's so good to hear tarceva and tagrisso have done so well for you.  I don't know the answer to your quesiton but I will ask for input from our faculty.  I hope your cancer continues to be controlled and you live your life to the fullest. 


Take Care,


Dr West

It should be feasible, but Tagrisso (osimertinib) and just about every other anti-cancer therapy hasn't been studied for safety in patients who are pregnant or may become pregnant. There is a chance that it could have a harmful effect on sperm or eggs, and I believe most or all clinical trials with Tagrisso exclude patients who are or could become pregnant. That risk may be small, but it is somewhat of an unknown.

The other issue is that we expect that Tagrisso will become less effective over time, so most people do not choose to have children with so many unknowns.

Good luck.

-Dr. West

JanineT Forum …



I don't know if that answered your question directly since there aren't data on the issue.  Though note that Dr. West does say that tagrisso could be harmful to eggs.  I'm sorry that there are so many unknowns.  I imagine in your years of treatment you've come to understand that there are more "unknowns" and "it depends" than easy answers in cancer care.  


You're in a very small subset of lung cancer, really rare so there just isn't a lot of info.  There are groups of people with rare diseases and rare subsets that find eachother out in the social media world.  I wish there was more to offer.


All best,