fanos
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Posts:18
The CimaVax vaccine was developed for NSCLC and it targets the EGFR overexpression. My daughters tumor tested negative for EGFR mutations. What effect does it have for EGFR positive mutations? Is the EGFR mutation even related to the vaccine? The article posted on Medscape says it targets EGFR overexpression found on approximately 40% to 80% of NSCLC. So how does one know if their cancer overexpresses EGFR and how much?
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Reply # - October 30, 2016, 09:14 AM
Hi fanos,
Hi fanos,
The CimaVax vaccine is not specifically directed at tumors with activating EGFR mutations. EGFR overexpression can be tested by staining the tumor tissue using a process known as immunohistochemistry (IHC).
Though this vaccine has shown promise in trials performed in Cuba, many experts in the rest of the world are waiting for more concrete proof of its efficacy, and trials in the U.S. and other locations are just beginning, so it may be some time before we have convincing evidence.
JimC
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