I just found this website and this forum while searching for information on Anti-PD-L1 so I thought I'd weigh in here if you don't mind.
I just started on the Phase1 trial of MedImmune's foray into the immunobiology race. The trial is named MEDI4736 and while it's the new kid in town it's showing the same potential as the trials from Merck and Roche. Or at least the lab rats at Cambridge think so. :-)
I'm a 52 year old male. Smoked for 30 years and I've always been on the bigger side of life so I fell into the perfect mixture for Esophageal Cancer. Thankfully we found it before it got to the point of causing any issues with swallowing but unfortunately it has already metastasized to the liver. I had 5 treatments of Folfox6 which according to my oncologist I was not handling as well as he'd like.
I've had 2 infusions of MEDI4736 and the only side effect so far was sleeping like a bear the evening of the first infusion. No nausea, very minor lethargy, no pain or any form of neuropathy and thankfully no cold sensitivity. Whether this drug is actually doing anything is yet to be seen but quality of life is back to being a 10.
I have one more treatment next Monday and then go back in for a liver biopsy and CT Scan the week of Thanksgiving. Hopefully we'll have lots to be thankful for.