I’ve been on a Crizotinib clinical trial for 10 months. Recent back pain prompted my Dr to order an MRI on my back and it showed activity on my spinal lesions. Not so much as to threaten my spinal cord yet, but enough to warrant having certain vertebrae radiated as a pre-emptive and pain-killing move. However my CT scan, done the day before the MRI, shows the drug continues to be effective against the original tumor and other small metastatic tumors in my kidneys and liver (one on my kidney has even been “no longer visible” for two months).
The need to be radiated means, just as part of the protocol, I have to be taken off the clinical trial. I will start Alimta infusions in lieu of the Crizotinib.
I’m disappointed that I will no longer be taking the Crizotinib since it does seem to continue to show effectiveness in some areas, and I can see that I should take a break from it if there’s a medical need to do so, concurrent with radiation. But I would like to continue with it after the break.
Is it possible to make this sort of choice, i.e., stop Crizotinib because of the rules of the clinical trial, be radiated, and then take up once again on “Xalkori” afterward? Wouldn’t it make more sense than starting Alimta, if the drug has shown effectiveness? Or are we betting that the Alimta will show effectiveness against the bone lesions where the Crizotinib has stopped being effective?