NSCLC HER2 Mutation Treatment - 1270461

michigan
Posts:2

First, I want to say “thank you” for creating this forum where patients and their families have a chance to ask questions and get feedback from experts that they may not have access to otherwise. It is so appreciated at a time like this. My mom was diagnosed with Stage I lung cancer in 2007 in her right upper lobe. This lobe was removed using the VATS procedure and no further treatment was deemed necessary. She diagnosed again in 2011 with Stage I adenocarcinoma lung cancer and since it was confirmed to one spot, it was treated with Stereotactic Radiosurgery and no further treatment was deemed necessary. She has now been diagnosed again this month with Stage II B adenocarcinoma lung cancer with the HER2 mutation. This time there are multiple spots in her middle right lobe as noted on the PET scan. She is a very healthy, active 79 year old that is currently not on any other medications. She was told surgery to remove the middle lobe was too much for her. She is looking at treatments with oral drugs specifically afatinib although combination treatments sound more promising after reading through your site. Are there any clinical trials that she would be eligible for given her history and tumor type?

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JimC
Posts: 2753

Hi michigan,

Welcome to GRACE. I'm sorry to hear of your mom's new diagnosis. If you are interested in clinical trials, I would suggest searching clinicaltrials.gov . I searched that site using the search term "NSCLC AND HER2" and came up with these results: https://www.clinicaltrials.gov/ct2/results?term=NSCLC+AND+HER2&Search=S…

Targeting the HER2 mutation has been discussed in few GRACE podcasts, which you can find here: http://cancergrace.org/lung/tag/her2/

Good luck with the treatment chosen, and don't hesitate to post any follow-up questions you may have.

JImC
Forum moderator

michigan
Posts: 2

Jim - Thank you for your quick reply and the information. The doctors want to use afatanib first line and since it sounds like the sample showing afatanib's efficacy with HER2 mutations was too small to draw conclusions, I wanted to see what else was out there. I will review the clinical trials and see what I can learn.

Thanks again....Michigan.