My mom (68y old) was diagnosed with poorly differentiated stage IV NSLCLC lung cancer with mets to liver, bones and brain almost 9 months ago. At the time of diagnosis and since the drs coudn't locate the tumor's primary sight right away, we did further testing + markers tests and she had TTF1 + as well as EGFR+ and PDL =90.
She was put on 80mg/day Tagrisso as her first line treatment and showed excellent response the first three months (her tumor almost disappeared to the astonishement of all the drs..) then unforuntately showed progression after another 3 months. the DR now decided to stop tagrisso and put her on chemo (Alimta + Carboplatine).
I hope someone can help me answer the following:
- The dr said that since mom's cancer is poorly differentiated, it is an agressive type of cancer and that it was expected that she would show great response at the beginning to tagrisso but that she will also relapse quickly. does this mean she will do the same to chemo?
- since mom has EGFR+, i read that those patients with this type of mutation do not respond well to immunotherapy; my mom however has a very high PDL (=90). dr said that in her case it might be different and that he plans to use this after chemoresistence. what are your thoughts on this?
Thansk in advance