Afatinib after Tarceva EGFR Exon18

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Afatinib after Tarceva EGFR Exon18

Hope somebody can help me.

Mum diagnosed with stage iv NSCLC in May of last year with spinal meta. Oncologist said she was a prime candidate for pembrolizumab. After 5 treatments oncologist said it didn't work as primary tumour had grown. 
oncologist the said that Mum had EGFR Exon18 and that Tarceva would be best option. After 3 months on tarceva Mum now has small mets on brain x 3 and two on liver. Oncologist now says that chemo only option.

i have done some reading which says that the ideal targeted drug for Exon18 mutation is Afatinib and suggested same to oncologist. She doesn't like to be challenged and was dismissive of afatinib as an option stating that side effects would be too severe despite the fact that dosage could be tailored to 20mg to mitigate risk of AEs.

I really believe that afatinib at 20mg is the best option for my Mum. How do I get the oncologist to give this option the appropriate attention.



JanineT Forum M...
Hi Paul, Welcome to Grace.  I

Hi Paul,


Welcome to Grace.  I'm very sorry that your Mum is experiencing any of this.  It is typical to have special circumstances with most any cancer diagnosis.  So it's impossible to say that your Mum's next best treatment option is afatinib though on the surface it would seem so.  If she had significant side effects from tarceva then it's likely the side effects from afatinib will be worse.  Chemo may be a good option.  Side effects from chemo have been significantly reduced in the past 15 - 20 years and could be negligible for many people. 


To your question.  Ask the oncologist to explain her decision-making process.  What are the pros and cons of the 2 treatment options?  What is the expected difference between the standard exon 18 treatment afatinib and chemo?  Giving an egfr inhibitor after being exposed to immunotherapy has caused a significant number of people to develop life-threatening pneumonitis.  Communication is key.  There might be a good reason to seek chemo now. 



If your mum is interested a second opinion from a lung cancer specialist at a large research center is never a bad idea.  This is an excellent guide for a 2nd. 


I hope this is helpful,


JanineT Forum M...
Paul, I see your mum has



I see your mum has taken pembro.  Unfortunately, very recently it has been discovered that taking an egfr tki after an immunotherapy can cause life-threatening pneumonitis.  Most oncologists are very hesitant to do that.