Stage 3 lung cancer and cerebellar atrophy re-immunotherapy - 1290039

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willis3
Stage 3 lung cancer and cerebellar atrophy re-immunotherapy - 1290039

Hi I was diagnosed with Stage 3 advanced adenocarcinoma of the lung spread to lymph nodes in August 2016.I have had 4 rounds of cisplatin/pemetrexed and 4 rounds of pemetrexed maintenance. CT shows all has shrunk and is stable. I also have cerebellar atrophe which causes balance problems. I have tested positive for immunotherapy but my oncologist is very cautious as this could affect the cerebellar problems.He thinks it could be paraneoplastic syndrome. My question is would I be able to have immunotherapy?

JimC
Hi willis3,

Hi willis3,

Welcome to GRACE. I'm sorry to hear of your diagnosis, but it's good that your cancer has responded well to treatment. As Dr. West wrote in his post on paraneoplastic syndromes, these are most often (but not exclusively) associated with small cell lung cancer. If your cerebellar atrophe was caused by your cancer, then from what I've read immunotherapy will not help, although I haven't found anything that indicates it would be worsened.

On the other hand, there are many conditions which can cause cerebellar atrophy. Since paraneoplastic syndromes are usually found in connection with small cell lung cancer, your medical team may want to perform further workup to try to rule out other causes for the atrophe, especially since there is evidence that immunotherapy may actually help the atrophe when not caused by cancer. That may require consultations with experts from fields other than oncology.

JimC
Forum moderator
.

<p>I began visiting GRACE in July, 2008 when my wife Liz was diagnosed with lung cancer, and became a forum moderator in January, 2010. My beloved wife of 30 years passed away Nov. 4, 2011 after battling stage IV lung cancer for 3 years and 4 months</p>