Husband on Clovis trial since July 2015. Has overcome several side-effects, the newest being diarrhea 3-4 x per day, his cough has been more persistent, 15 new brain mets that were treated on Friday with GK, last GK treatment 6 months ago. Also, recent CT showed a spot on the liver. He is EGFR Exon 21.
He has lost about 8 lbs, but this could be from the diarrhea, the endocrinologist stopping insulin plus he has had to fast a couple of x for appointments.
1. Given these side-effects, the 15 new brain mets that were just treated with GK on Friday and a spot on is liver, wouldn't it be prudent to get out of the Clovis trial and go onto Tagrisso since he has had luck with Tarceva as far as controlling his micro disease in his brain?
2. Does Exon matter as far as Tagrisso's effectiveness... my husband is "Exon 21"?
As always, thank you.