I haven't been on in a while and just wanted to keep you all updated.
My wife is still on Enhertu and it has been great, continual decrease in size, until about 2 months ago when the results seemed to be mixed. Everything was good (decreasing or stable) except for two lesions that seemed to be growing in her liver, but they were in a peripheral, accessable place, and so they did some microwave ablation on them.
Well, she just had her latest CT and again the results are mixed. We first got the brain CT portion results back and we were elated - all of the brain lesions continue to decrease in size, many are negligible, and a few are now undetectable (at least at the CT level). However, later in the day we got the liver results - many of the lesions are now beginning to increase in size. A couple are decreasing, but those are the ones treated by the ablation.
So, we are once more in that place we have been before, where the results are mixed. We will know more once we talk to the oncologist on Monday (and the restirctions are now lifted enough that I can actually go in with my wife!). Once more into that anxiety whirlwind of wondering how long this Enhertu will last and if it stops, what will be next. I am sure given the great results on the brain lesions she will be able to stay on it for a while still (she is on the drug via expanded access/compassionate care), but I know the oncologist is really concerned with the liver.
But, at the very least, her liver is back to where it was about a year and a half ago, and likely several months away from any liver crises - even if the drug completely stops working, which does not seem to be the case yet. Her next CT, whenever that is some weeks from now, along with any changes in the liver enzyme and chemistry blood tests over the next few weeks, will be the telling part of which way things are going.
And she is now fully vaccinated! Who knows, perhpaps the vaccine interfered with the last chemo and all is still good.
Anyway - day by day - we still cherish each moment together. And our days with our children and grandson.