VAXIRA - 1271977

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captain72
VAXIRA - 1271977

HI

Looking for some insight please

NSCLC EGFR Exon 19, diagnosed 2103, 40 YOA, Never smoker, NED on Tarceva for 27 months, currently on trial with Tarceva and BKM 120 due to slight progression, currently stable. Recently did GUARDANT360 with no trace cells of any kind detected

I've been approved to receive VAXIRA in Cuba. I've searched high and low for the answer to this.... .I'm willing as in my onc for me to try VAXIRA, however my onc plans on putting me on Opdivo at some point. Since Vaxira and Opdivo are both immunotherapy drugs, would they conflict with each other even though they have different mechanism of actions ?

Thank you

http://www.vaxira.com/eng/vaxira.php

JimC
Hi captain72,

Hi captain72,

Though it has been around for a number of years, Vaxira/Cimavax has not really generated much of any interest outside of Cuba. For example, there are no trials listed on clinicaltrials.gov. Last year, Dr. West wrote this about the drug:

"Cimavax is a hard one to speak to, since there’s really been no more evidence presented on it since the post I did years ago. Frankly, that makes me skeptical, especially since no lung cancer specialist outside of Cuba has ever given it a moment of thought in the last 3 years. If it were that impressive, it would have been championed by someone, somewhere. But the short answer is that there’s no additional evidence to offer beyond the immature, rather weak evidence in the post Jim cited."
- http://cancergrace.org/topic/squamous-nsclc-treatment-after-discontinued... (Unfortunately, the post referred to in this comment does not seem available now).

With different mechanisms of action, I would think that a trial sponsor might be concerned that they could conflict. You would want to check in advance whether prior treatment with Vaxira will disqualify you from a specific trial of another immunotherapy agent.

JimC
Forum moderator

<p>I began visiting GRACE in July, 2008 when my wife Liz was diagnosed with lung cancer, and became a forum moderator in January, 2010. My beloved wife of 30 years passed away Nov. 4, 2011 after battling stage IV lung cancer for 3 years and 4 months</p>

carrigallen
Here is what I understand

Here is what I understand about VAXIRA:
- Even though VAXIRA is technically a monoclonal antibody, its mechanism of action is fairly comparable to a peptide-based vaccine. Peptide-based vaccines have largely been a disappointment in lung cancer.
- VAXIRA has been approved by regulatory authorities in Cuba and Argentina, which is where the product is manufactured. Drug approvals can have political importance. There is no high level double-blinded evidence to support its use yet.
- I personally have also not heard of any dramatic confirmed tumor shrinkage with this drug.
- I'm looking at the Recombio website, I see there have been no press releases since May 2013.

If anything, in general, it seems reasonable to wait and have the cancer vaccine at the same time as the Opdivo. From a theoretical standpoint, that would be the best time for antigen presentation.

captain72
Thank you for your replies.

Thank you for your replies. You've given me more insight than my onc has. Just trying to be as proactive as possible. Never been the wait and see type. Seems like there are a few new options albeit I don't have T790 or PDL markers. The Vaxira interested me because it seemed like Roswell Park can't wait to trial it.

Anyway, thank you. Have a important decision to make :(