SBRT as a Potential Alternative for Fit Patients with Early Stage Lung Cancer

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Dr. Jeffrey Bradley, Radiation Oncologist at Washington University in St. Louis, provides evidence for the use of stereotactic body radiation therapy as an alternative to surgery for operable early stage lung cancer.


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There has been a growing interest in stereotactic body radiation therapy in the United States and across the world. As patients have come to learn about this, they have sought alternatives to surgery today. Now, surgical techniques have improved — minimally invasive surgery has proven to be quite effective in eradicating early stage lung cancer, but there is a good alternative in stereotactic body radiation therapy, and the literature is coming out now that SBRT probably offers equivalent cure rates and equivalent outcomes to minimally invasive surgery or lobectomy for early stage lung cancer.

The best example of that is a randomized trial published in The Lancet Oncology this past May. It was a randomized trial from two centers, or two groups, one in the United States — an Accuray trial comparing lobectomy to radiosurgery or stereotactic body radiation therapy. The second trial was in the Netherlands, the ROSEL trial, and it also compared patients with lobectomy to stereotactic radiation therapy. Neither trial was able to meet its accrual goals — both under-accrued and were closed due to lack of accrual. So, taken individually, these trials couldn’t give us the answer about this comparison, but the authors and the groups decided to combine the data and publish the data, and the data indicate that SBRT, in this series, proved superior to surgery in this population.

This has caused quite a controversy today. Needless to say, I think stereotactic radiation therapy does offer a reasonable alternative to surgery. Other trials are needed to prove that this is the case since that trial was underpowered to show a true difference, although it does indicate that SBRT is at least equivalent and should be considered for these patients.

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