Nexavar (Sorafenib) Shows Survival Benefit for EGFR Mutation-Positive NSCLC but Fails in Broader Population

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It has been a long time since we've talked about Nexavar (sorafenib), an oral anti-angiogenic targeted therapy that works as a "multi-kinase inhibitor"  and is FDA approved in some other cancers such as renal cell and liver cancer.  In lung cancer, some small, early research done years ago revealed that it has activity in at least a minority of patients with advanced NSCLC.

Lesser Known Lung Cancer Mutations Part 2: BRAF inhibitors as another targeted therapy bullseye?

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Recently, I described the rationale for targeting HER2 mutations in non-small cell lung cancer (NSCLC). Most of our experience with HER2 targeted therapy comes from studies in breast cancer. Now, I'd like to introduce you to BRAF, another novel target in NSCLC that is a central component in cell signalling, growth, and division.

Fighting a Good BATTLE: A Key Step in Molecular Oncology

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Though I didn't make it to the American Association for Cancer Research (AACR) meeting in mid-April, I did catch discussion that followed presentation of some preliminary data from the Biomarker-integrated Approaches of Targeted Therapy for Lung Cancer Elimination (BATTLE) trial, conducted at MD Anderson Cancer Center over the last several years. My friend and colleague, Dr. Ed Kim, presented the provocative early results. The study enrolled 255 patients with previously treated advanced NSCLC who had previously received a median of two prior lines of therapy.

Promising Lead on Potential Benefit of Nexavar (Sorafenib) for KRAS Mutation Positive NSCLC

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It's only 10 patients, but a brief report in the Journal of Thoracic Oncology that just came out today from a group in Amsterdam has gotten my attention because it suggests that the oral multi-targeted anti-cancer agent Nexavar (sorafenib) may be genuinely effective in patients with advanced NSCLC who have a K-RAS mutation.

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