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I met DC in April. He was 62 years old and was principal of a Montessori school. He had smoked a half pack a day for three years in college (which...

Several weeks ago, we were fortunate enough to be joined by not one but two international stars in lung cancer research that is being translated...

Continuing Dr. West's theme discussing new therapies for patients with acquired resistance, I'd like to answer a few questions about HSP 90 inhibitors...

It was almost exactly a year ago that I described the basic results of the global LUX Lung-1 trial that enrolled 585 patients with advanced NSCLC who...

Thank you fortmyr for bringing our attention to the recent publication of exciting data on talactoferrin. We've talked about talactoferrin before on...

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Tagrisso Prescribing information
Last Comment by Jim C GRACE Co… on Sep 30, 2018 9:11 am
Acquired resistance to Tarceva
Last Comment by Jim C GRACE Co… on Sep 30, 2018 9:11 am
The Tagrisso prescribing
Last Comment by Jim C GRACE Co… on Sep 30, 2018 9:11 am
Targrisso for acquired resistance to Tarceva
Last Comment by Jim C GRACE Co… on Sep 30, 2018 9:11 am
Can Tagrisso be used for patients with no T790M mutation
Last Comment by Jim C GRACE Co… on Sep 30, 2018 9:11 am

Ongoing Great Panel Discussion from the Santa Monica Molecular Markers Webinar: Part 4

Video

Here's the next installment of the panel discussion on molecular markers from the webinar in Santa Monica with Drs. Charlie Rudin, Alice Shaw, David Spigel, and Glen Goss.  We continued our animated discussion on the promise as well as the pitfalls of broadening the use of molecular markers in routine practice of managing patients with advanced NSCLC.

Molecular Markers in Lung Cancer: Dr. Charlie Rudin on the Lung Cancer Mutation Consortium

Video

This is the first of a series of podcasts from the two hour special webinar we did in partnership with the LUNGevity Foundation at the Santa Monica "Targeted Therapies in Lung Cancer" meeting several weeks ago.  There, I was privileged to be joined by four excellent guest faculty members -- Dr.

Low Testosterone with XALKORI (Crizotinib): A Newly Identified Side Effect

Article

It started with a patient reporting an unexpected side effect. A 35 year old ALK-positive man with lung cancer who was on XALKORI (crizotinib) noted that he had markedly diminished libido lower energy that had been worsening while on treatment, despite the fact that his cancer appeared to be responding well  His doctor checked his testosterone (T) level and noted it was well below the normal range, then referred him to the endocrinology clinic for consideration of testosterone replacement therapy, which he decided to do, and which helped with his symptoms.

Radiation to Address Cells with Resistance to Targeted Therapies

Article

Introduction

Thank you to member Craig for asking some excellent questions in response to my Highlights of 2011 webinar.  Thank you also to Dr. West, who emailed me to comment more on the idea of radiation for cells with acquired resistance.

We’ve spoken at length about EGFR and related mutations such as EML4/ALK and ROS1 on GRACE.  For those who are not familiar with these subjects, I will refer you to my webinar for a summary on the most recent data on EGFR, EML4/ALK and ROS1:

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