My father have been on Tagrisso for 5 years since 2015 with no progression until recently. Below is the new CT report in July comparing the CT in Jan 2020.

He did have EGFR with T790M positive. Tagrisso is the second-line treatment with Iressa as the first-line. My father does not have any symptoms at the moment.

We live in Toronto with the possibility of clinical trials. Will be seeing our oncologist this Thursday.

Would love to get your thoughts on the following question:

1. Unfortunately, there are some signs of progression with the two bone mets.

Hello, my father was in Tagrisso for 9 weeks. His symptoms started to deteriorate particularly having shortness of breath (although his pain was much better) so doctors did a bronchoscopy and a CT Scan and found progression. He has been switched to chemotherapy. A second opinion mentioned that he should have gotten a PET Scan and that there was not sufficient evidence to eliminate Tagrisso. We had such high hopes for the medicine that we are now with thoughts about if we did what was correct and if he can return to Tagrisso at some point in the future.

Hello,

Dear All,

My mom was diagnosed with a stage IV NSCLC with a LMD and hydrocephalus. In the begining a neuro surgeon installed a v shunt to create a bypass of brain liquid to the stomach and she had undergone 3D and SRT to treat a lesion at the back of her brain. After that she was given Tarceva before moving to Tagrisso despite her not having T790M mutation.

Hi everyone. I'm looking for anyone who has a BRCA2 mutation and advanced NSCLC. Husband is now taking PARP Inhibitor Lynparza b/c last year one of his second line treatments - Avastin - supposedly caused his colon  to perforate and his onc doesn't want to put him back on traditional chemo/immunotherapy. The Lynparza seems to be working - enlarged lymph nodes have gotten smaller.  Challenge is that Medicare won't cover it since it's off label for LC.

Hi, my mum developed resistance to Afatinib after around 7 months. Docs did a rebiopsy and found T790 mutation so they're switching her to Tagrisso 80mg. Would like to verify that the gap days from her last intake of Afatinib has to be at least 10 days before starting Tagrisso? I only found one material online regarding this which states that the median time between stopping Afatinib and starting Tagrisso is between 10-16 days. Many thanks! 

Hello. My mom has recently had a couple of episodes of dizziness accompanied by low blood pressure and night sweats.  She is on Entrectinib since October 2019.  I'm concerned about the impact of this medicine on the heart and would really appreciate any thoughts or recommendations you might have. Thanks so much!

Semone