shinbo
![]()
Posts:20
Hello everyone,
I was wondering if there is any sort of data or research out there that mention if having radiation or SBRT to tumors before getting treated to targeted therapies such as Tarceva/Xalkori will make the tumor more resistant to those targeted therapies?
It's just a thought that crossed my mind and wondering if there is anything to it.
Thank you
Dan
Forums
Reply # - February 21, 2013, 04:28 PM
Reply To: Can radiation to a tumor make targeted therapy less
Hi Don, If I'm reading this right it's opposite the order of Dr. Weiss' research but he may be the most likely doctor to have that answer. I'll ask him to comment.
Janine
forum moderator
Reply # - February 21, 2013, 10:14 PM
Reply To: Can radiation to a tumor make targeted therapy less
To my knowledge, there is no evidence to suggest this.
-Dr. West
Reply # - February 22, 2013, 07:47 AM
Reply To: Can radiation to a tumor make targeted therapy less
No, I am not aware of any data to support that idea. If anything, radiation might theoretically eliminate resistant clones and render patients more sensitive to targetted therapies. We currently have a research projects that uses SRS to try to restore sensitivity. If the trial is very succesful, we may next try to use radiation up front to increase sensitivity.
Reply # - February 27, 2013, 02:25 PM
Reply To: Can radiation to a tumor make targeted therapy less
Thank you doctors very much for answering my questions.
Reply # - March 2, 2013, 01:21 PM
Reply To: Can radiation to a tumor make targeted therapy less
shinbo,
Although it doesn't directly address your question, you might find Dr. Weiss's related article (and the discussion at the bottom) interesting:
http://cancergrace.org/lung/2012/04/03/radiation-to-address-cells-with-…
Best hopes,
Craig