Technical Biopsy Help Please - 1256657

Thanks in advance for your help with my father.

Background: Diagnosed 4 years ago. Main tumor DNA sequenced with no actionable results. Want to do RNA but having a hard time getting there (sigh). All known actionable mutations tested and resulted negative. Main tumor microwave ablated. Mets to brain, adrenal gland, lymph nodes, and multiple bones. Gamma knife 9 months ago and just recently had whole brain radiation. Been on every type of chemo for last four years. CEA is excellent indicator of tumor activity. Consistent cough – every 60 seconds, coughs 15 seconds (no exaggeration).

Problem: Recent needle core biopsy of central lung lymph nodes resulted in 6 cores. Burned through all of them as lab came back with not enough tissue to perform test(s). Oncologist wants to perform another biopsy from bone. CEA pre-biopsy 29, post-biopsy over 300. PET scan verifies. This is his 4th biopsy.
Historically, the largest jumps in tumor activity have been after biospy (similar results have occurred after each biopsy).

Questions:

1. During biopsy procedure, assuming surgeon and pathologist know specific lab requirements to perform a good test, as the pathologist looks at sample under microscope, can pathologist make the call if the sample meets lab requirements? Besides % tumor, and viable versus necrotic within tumor tissue, what else is the pathologist looking for? Please be specific.

2. Can microscope technology a pathologist uses during biopsy procedure help pathologist determine if lab criteria are met? Please be specific.

3. Outside of current hospital procedures, during a biopsy procedure, conceptually can a procedure exist where surgeon takes sample, pathologist verifies, sample is frozen and cut, DNA expression analysis occurs to determine if DNA meets lab requirements, results given to surgeon to determine if he needs to get more samples?

Very scared of doing another biopsy and would like these answers to help insure a different result