My mom was diagnosed with a stage IV NSCLC with a LMD and hydrocephalus. In the begining a neuro surgeon installed a v shunt to create a bypass of brain liquid to the stomach and she had undergone 3D and SRT to treat a lesion at the back of her brain. After that she was given Tarceva before moving to Tagrisso despite her not having T790M mutation.
Recently her condition deteoriated (unable to walk, control bladder, issues with talking and hearing) and it is very clear that her CNS had been affected by LMD and upon doing a spine MRI, we found out that it has entered the spine, (My guess is even back then it has entered the spine since my mom had difficulty walking for the last 2 years before even we did the MRI scan). Her MRI Scan says "There are hyper intense lesion at posterior intervertebral disc L4-5 and L5-S1 suspected annular tear. There is enhancement of durameter with skip lesion at level cervical, thoracalm lunar and conus medulla."
In the begining we have 4 options:
- Omaya Reservoir to pave a way for Chemotherapy to the spine, but due to the shunt to eradicate brain liquid, she has too litle brain liquid for us to proceed with Omaya installation and I heard this method's efficacy is not great compared to the risk associated with this procedure
- Immunotheraphy which is no longer possible since she is an EGFR positive patient in the past and I heard Immunotheraphy is not going to be efficient
- Radiation to the entire spine which we are going to do since we are left with this option now
- Double Dose Tagrisso (I have been hearing a lot of positive results from this treatment)
Our main Oncologist told us that there is nothing much we can do now unless we want to do radiation (will be done tomorrow) + double Tagrisso. How dangerous is Double dose Tagrisso? Can we start the double dose Tagrisso while she is doing her radiation or should we wait until radiotheraphy is done? Is there any other treaments that we can consider? I felt really helpless now, but I refuse to just wait until the day she is called back to heaven. If there is any kind soul who has any information, please help to enlighten me.
Thank you and cheers.