Hello, my mother was diagnosed with stage 4 lung cancer with metastasis to different areas. She is a 50 year old lady (non smoker). Our oncologist at UCSF put her on Tagrisso when she was first diagnosed, in which it has reduced the tumor by a lot in her lung. About 4 months ago, her symptoms, behaviors and body functions have drastically changed and continuously get worse. Our oncologist also doubled her tagrisso dose about a month ago, to ensure treatment. Lately, she has had impaired speech, her motor movement have weakened and has loss of balance.

My husband was diagnosed stage 4 NSCLC with EGFR 21 exon L858R in Sept 2022. He started Tagrisso end of Sept 2022. The size of tumor before treatment was 3.4x2.2 cm, Nov 2 CT showed 2.8x2.2 cm, Dec 14 CT showed 2.9 x2.1 cm. He also had large pleural effusion from the beginning without change. Basically no improvement in the past 6 weeks. He felt better than before treatment with minimum symptoms. Is Tagrisso working in his case? We are disappointed that there is no continue shrinkage for the tumor. Do you think adding other treatment such as chemo, to Tagrisso would help ?

Hi, my mother was diagnosed with stage IV adenocarcinoma with brain metastases 15 months ago. After all the analyses, it was determined that he has a mutation for which he is suitable to take Alecensa-Alectinib. After the initial use, her condition improved drastically. An intermediate CT scan from more than a month ago shows progression at one point, in the primary tumor. Head metastases are smaller. So, oligoprogression is at one point. We are a little disappointed because we read that Alecensa works for up to 37 months.

My 81 year old mother was recently diagnosed with stage 4 adenocarcinoma with metastasis to her spine along with a malignant pleural effusion (no other organ involvement and negative for brain meta sis). Prior to this she had been suffering from rheumatoid arthritis and was taking Embrel, a biologic, which her physicians suspect may have contributed to the cancer (she never smoked a day in her life).

Wife 50 years old , diagnosed with lung cancer in May 2022 – adenocarcinoma ,L858R, exon 21, T790M not detected.
Tumour right lung lower 2.5 x 1.8 and met on left lung and 8th ribs .
On Tagrisso – 2 days once and on 3 Oct – CT scan show tumour side 1.7 x.16 and left lung clear and bone met numbers lower.

Diagnosed 2018 with a malignant pleural effusion - no solid tumour. EGFR Mutation and have been on Osimertinib since.
The last week I have right side discomfort and the past day or so pain mid/lower back (right side) mainly at night.
Breathing is OK.

My mom (age 66) was diagnosed with late stage NSCLC last week... metastasis to brain and through to scalp across skin. Has anyone experienced this metastasis? We haven't even been able to address treatment - waiting on spine MRI. This is all happening quickly.

I was dx Stage 4 squamous NSCLC with MET amplification mutation. I have been looking for 3 years for others that have squamous with any mutation. I'm told I'm a bit of a unicorn, but was looking to connect with others.

I'm on the targeted therapy, Crizotinib, and have been stable for a little over 3 years.

Thank you!

Hi everyone, my father has been diagnosed with Stage IV NSCLC in 2013 with metastasis to the pelvic region. The biopsy at the time revealed tumor cells positive for CK7 and TTF-1 and negative for CK20. EGFR gene analysis revealed 2 mutations on exon 19. The bone lesion was permeative destructive centered along the right acetabulum, resulting in severe pain and significant in mobility issues.

4/4/22 ER found large mediastinal mass via CT with contrast “A massive area of adenopathy in the subcaranial region that means urges 11.3x6.1x7.7cm with lung consolidation” and pleural effusion - right lobe

Mom was in decent health prior with no oxygen requirement and some health issues related to emphysema/COPD, as well as hemochromatosis. 50 year history of smoking ciggarettes and stopped 3/4/2022. Social drinking only.

Transferred to Shands UF Gainesville same date and has been inpatient to date.