After three months off of treatment I've progressed very slightly and will be going back on some sort of treatment. The options at the present time are Afatanib at half-dose or back on Alimta/Avastin or Alimta maintenance. I had a year of first line treatment with Tarceva and progressed and presented T790M mutation. I then went on Clovis and progressed there. Then on to chemo.
So I'm wondering if anyone else has gone from Tarceva to Afatanib and if so, with the T790M mutation. I don't want to assume that the resistance created to Tarceva by T790M isn't applicable with Afatanib.
I'm also curious as to the degree of SE's with Afatanib. I hated Tarceva and couldn't wait to get off but I've heard both sides on Afatanib.