Dear Madame, Sir,
My mum (68yrs) was diagnosed in february with Adenomacarcinoma with pleural metastasis. As in her DNS sample in exon 21 of the EGFR gene p. L858R activating mutation is found in 57%. She's now Iressa for 2 months now. She is currently in good condition, with small weight loss.
(No genetic difference in codons 12 and 13 of exon 2 of the kras gene in the dns sample. No genetic difference was detected in codon 600 of the BRAF gene in the dns sample. No genetic differences were found in exons 18 and 19 of the EGFR gene. PD-L1 immunohistochemistry reveals membrane positivity in 2% of tumor cells).
As I'm new in this topic and don't have much information on this, could you help me to provide more info just to be prepared and informed about the future possibilities.
What happens if the targeted therapy stops to work after a while? Will it be possible to have a new NIVATS biopsy (from the cells with resistance) and see that are there any new mutations? If yes, are there other targeted therapies that may work in similar situations? Or in this cases only the chemotherapy and radiation therapy can be possible? Or clinical trials? Or in that cases the condition of the patient will decide if there will be any possibility to continue any treatments?
We are at the beginning of this new fight (she had breast cancer in 2004), and I'd like to see the possibilities to be prepared to help my mother.
Thank you very much for the answer in advance. And sorry for so many questions.