Last July my partner of 15 years was diagnosed with stage 4 bladder cancer with mets to the bones. In August 2012 he started chemo - 2 cycles of cisplatin and gemcitabine and then (because of compromised kidney function) 4 cycles of carboplatin and gemcitabine. He had reasonable success with this regime - it shrank the primary tumour, lymph nodes and stopped the mets advancing. Since finishing chemo in December he has been on a trial with lapatinib as maintenance. Unfortunately, a recent scan showed that the cancer was on the move again. There now seems to be several options:
1. To start the carboplatin and gemcitabine again (maybe it will be effective for a short amount of time)
2. To enroll for a two armed clinical trial with either pozaponib (Votrient)or paclitaxel (Taxol)
3. To start carboplatin and paclitaxel.
4. To start gemcitabine and paclitaxel
I was wondering do you have any general research/thoughts on any of these combinations?