My wife was diagnosed with stage 4 adinocarcinoma NSCLC /EGFR with mets to liver, bones and brain in Sept. '12. Immediate surgery to replace right hip followed by 5 DVT's in legs in September. Started Tarceva in October. Surgery to right femur in January to stabilize femur. Radiation treatment to right femur in February. Radiation treatment to left femur in April. In May we learned that the cancer had spread to her spinal fluid - she has Leptomeningeal disease. She has been on pulsed doses of Tarceva for 4 weeks now and recent MRI indicates no progression (thank God), but our oncologist told us today that when pulsed doses of Tarceva stop progression he has no good options but hospice care. He said our prognosis is months rather than years.
Today was pretty tough for us because we are running low on hope. Are any of you aware of any clinical trials to stop progression of LMD in patients with NSCLC exhibiting EFGR? Are there any treatments that have had some success that anyone knows about? Still hopeful in St. Louis.