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Can you talk a bit about the above? My husband has low level or low grade in both lungs, lymph nodes in chest and possibly 2 spots on liver. He is getting cisplatin/etopiside and now radiation to neck where enlarged by tumor. Also waiting for genetic test results. Is this an appropriate course of treatment? Is genetic mutation likely in a 67 otherwise healthy non-smoker? Thank you!!!
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Reply # - June 30, 2014, 08:46 PM
Reply To: Neuroendocrine lung cancer stage 4
Here's are a couple of posts in which we discuss large cell neuroendocrine carcinoma:
http://cancergrace.org/lung/2007/03/22/lcnec-tumors/
http://cancergrace.org/lung/2010/01/28/interview-with-dr-matthew-horton…
It's always reasonable to do genetic testing in never-smoking patients with a lung cancer, but neuroendocrine carcinomas are relatively unlikely to harbor an "actionable" mutation such as EGFR or ALK. We often favor chemotherapy with a combination of a platinum agent (cisplatin or carboplatin) and etoposide.
Good luck.
-Dr. West