Will 600 mg every four day tarceva shotten the required resistance period? - 1255110

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fred9999
Will 600 mg every four day tarceva shotten the required resistance period? - 1255110

As tittle, If I use 600 mg every four day tarceva to treat my mum 's leptomeningeal carcinomatosis. Will this cause the required resistance coming earlier? As the cells of tumor will be under huge pressure of tarceva. I assume that will force 'the tumor' to pick up new cells which has required assistance.

JimC
Reply To: Will 600 mg every four day tarceva shotten the

Hello,

That Tarceva dosing schedule has not been studied sufficiently to know whether it speeds acquired resistance. In the setting of leptomeningeal carcinomatosis, unfortunately there are not many available and effective treatments so the rate of acquired resistance is probably of less importance than the efficacy of the pulsed Tarceva regimen.

Good luck with this treatment.

JimC
Forum moderator

<p>I began visiting GRACE in July, 2008 when my wife Liz was diagnosed with lung cancer, and became a forum moderator in January, 2010. My beloved wife of 30 years passed away Nov. 4, 2011 after battling stage IV lung cancer for 3 years and 4 months</p>

Dr West
Reply To: Will 600 mg every four day tarceva shotten the

Jim's right that there's no study of this question, so it's just an unknown.

-Dr. West

+++++++++++++++++++++++++
Dr. Howard (Jack) West
Associate Clinical Professor
Medical Oncology
City of Hope Cancer Center
Duarte, CA

Founder & President
Global Resource for Advancing
Cancer Education