Article and Video CATEGORIES

Cancer Journey

Search By

Chief of Hematology/Oncology and Medical Director at Memorial Cancer Institute, and Clinical Associate Professor of Medicine at Florida International University

Chief of Hematology/Oncology
Medical Director of Memorial Cancer Institute

Lung Cancer Video Library - First Line Immunotherapy for Advanced Non Small Cell Lung Cancer NSCLC
Thu, 06/29/2017 - 06:00
Luis Raez, MD FACP FCCP, Faculty, Board Member



We welcome Dr. Luis Raez, MD FACP FCCP, Chief of Hematology/Oncology and Medical Director at Memorial Cancer Institute, and Clinical Associate Professor of Medicine at Florida International University with 2017 updates to our Lung Cancer Video Library.  In this recent video for GRACE, Dr. Raez discusses First Line Immunotherapy for Advanced Non-Small Cell Lung Cancer NSCLC.



download here

 Dr. Luis Raez, MD FACP FCCP

Chief of Hematology/Oncology and Medical Director, Memorial Cancer Institute
Clinical Associate Professor of Medicine, Florida International University

These are very exciting times because we have recently moved immunotherapy to first line, meaning new patients with stage IV non-small cell lung cancer or metastatic patients.   Until recently immunotherapy was approved first for second line and based on some studies - very important - but immunotherapy, after that moved to the front line, so that new patients can have an opportunity to be treated.  Specifically, the Pembrolizumab was moved to the front line based on a study in which the Pembrolizumab was compared against chemotherapy, Carboplatin combination that are the standard of care so far and Pembrolizumab was able to give better outcomes than the combination or amalgamation of chemotherapy but the most important thing in this news is that we are developing markers to try to discover which patients will respond to immunotherapy and which ones will not.  The specific marker that probably everyone knows or cares about is PD-L1.  In this specific study, the patients will benefit from immunotherapy for new patients if the PD-L1 expression in the tumor, we are checking in the tumor, is more than 50%.  Immunotherapy front line was not approved for everybody, it was approved for this specific niche of patient that they will benefit.  The rest of the patients will still need to get chemotherapy or target therapy based on molecular markers if they have any of these genetic alterations that we reference all the time, EGFR, ALK, ROS1.  We only had one drug approved because unfortunately the other drug, Nivolumab, is already approved for second line.  In a similar study, Nivolumab was much against chemotherapy and Nivolumab was unable to get a better progression free survival than the patients on chemotherapy.  For that reason, we only have as a single agent so far, Pembrolizumab, approved in first line.  Of course, there will be changes because we have other immunotherapy agents coming to the market soon and new studies coming soon but so far Pembrolizumab is only approved as a single agent in the front line.  



Video Language

Next Previous link

Previous PostNext Post

Related Content

Forum Discussions

Hi JW and welcome to Grace. I'm sorry you're going through this but hopefully and probably this isn't cancer. There is so much going on anatomically in that area that the...

Thanks Janine! I really appreciate your feedback. Had the CT and it came back all clear, huge relief! Going the physical therapy route which has already made a big difference. Root...

That is fantastic J_W! We really appreciate your follow-up. So many people find us through the same route you've taken/pinched nerve and like people with a cancer diagnosis it's important to...

Hi and welcome to Grace. I'm so sorry about your mom's situation, it's very complicated and not at all reasonable for us to comment on all that is being taken into...

Hi Scruboak, I will ask Dr. West to comment, it may be tomorrow. He's an expert in the field and will have thoughtful input. The fact that it was caught and...

I asked Dr. West and he said that this is a question he can't answer, we don't have studies that give details that specific. He said to his knowledge, that this...

Thank you so much, Janine. It helps me to just chill overall.

Recent Comments

From Dr. West
By JanineT Forum … on Fri, 05/27/2022 - 13:29
Hi Rowan,  I'm sorry you're…
By JanineT Forum … on Fri, 05/27/2022 - 08:55
Progression on tagrisso
By JanineT Forum … on Fri, 05/27/2022 - 02:50
That is fantastic J_W! We…
By JanineT Forum … on Thu, 05/26/2022 - 09:40