In Treatment

My wife is taking treatment for EGFR mutant lung cancer that had spread to her brain. She started with tagrisso and later after resistant went thru chemo drugs and they are not helping.  We are planning to try erlotinib (tarceva). The recent molecular shows the mutant as EGFR e746_s752 (exon 19 deletion ) and same as it was before 2 years ago except it had formed resistant to egfr c797s so tagrisso did not work. 

Hi, my sister (47 YO, Seattle, WA) was diagnosed with lung cancer (non small cell adenocarcinoma) spring 2019. She had symptoms for a year before that, but her doctor at the time failed to do additional tests, she had ground glass on her scans and was being treated for pneumonia. She is now being treated at Virginia Mason in Seattle. June 2019 her lower and middle lobes of the right lung were removed with negative margins, 22 lymph nodes were removed and were all negative for cancer. The stage was determined as 3A. Her blood biopsy showed mutation EGFR T790M.

My sister was diagnosed with IMA lung cancer this July. It was found during the physical exam. She is 55 years old, otherwise very healthy and active, and has never smoked. Since the tumor was very big, 4.4 cm, the doctor scheduled surgery and removed the lower lobe of her right lung in mid-July and said it is stage 2A. The PET scan and the examination of the tumor tissue did not find any spread.

My father have been on Tagrisso for 5 years since 2015 with no progression until recently. Below is the new CT report in July comparing the CT in Jan 2020.

He did have EGFR with T790M positive. Tagrisso is the second-line treatment with Iressa as the first-line. My father does not have any symptoms at the moment.

We live in Toronto with the possibility of clinical trials. Will be seeing our oncologist this Thursday.

Would love to get your thoughts on the following question:

1. Unfortunately, there are some signs of progression with the two bone mets.

Hello, my father was in Tagrisso for 9 weeks. His symptoms started to deteriorate particularly having shortness of breath (although his pain was much better) so doctors did a bronchoscopy and a CT Scan and found progression. He has been switched to chemotherapy. A second opinion mentioned that he should have gotten a PET Scan and that there was not sufficient evidence to eliminate Tagrisso. We had such high hopes for the medicine that we are now with thoughts about if we did what was correct and if he can return to Tagrisso at some point in the future.

Hello,

Dear All,

My mom was diagnosed with a stage IV NSCLC with a LMD and hydrocephalus. In the begining a neuro surgeon installed a v shunt to create a bypass of brain liquid to the stomach and she had undergone 3D and SRT to treat a lesion at the back of her brain. After that she was given Tarceva before moving to Tagrisso despite her not having T790M mutation.