In Treatment

My mum (73years,IVstage,small meta in lymph nodes,EGFR+,exon18,G719X), was for 21 months on 1st line Afatinib (first 40% reduction, last three months with slow progression), after that she was on pemetrexed monotherapy for 3 months with quite significant progression (30%). Since finishing on Afatinib 3 liquid biopsies for T790M have been done with no outcome - not even the original mutation showed. Tissue biopsy would be problematic.

Is anyone on Tagrisso (osimertinib) taking or took dexamethasone? I want to start my mum on osimertinib, but she is taking dexamethasone for brain lesion edema. I learned there might be interaction between these two : dexamethasone may reduce the blood levels of osimertinib, which may make the medication less effective in some cases. Does anyone have any experience or recommendations and did you have good response from Tagrisso while on dexamethasone?

History- Diagnosis in February, metastasis to thyroid, lymph nodes, chest wall. Malignant pleural effusion-had pleurex cathether which was recently removed due to little fluid. Pdl1 40%, KRAS mutation

March 26, 2018 at 10:40 pm #1294138

March 26, 2018 at 8:36 pm #1294136

onthemark
I’ve got two stable ground glass small lesions (one 5 mm and another faint one 5x9mm) in my right lung and have been reading about other people’s experiences with them on the web.

On a different forum it is often stated that these lesions rarely grow large, but I thought it was the case that they can grow large but are not called AIS when they grow to larger than 3 cm so it is only a question of definition rather than related to the natural life history of these lesions.

March 20, 2018 at 2:04 pm #1294118
JimC Forum Moderator
JimC Forum Moderator
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