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Infection and inflammation seem to be the two primary reasons given for elevated, non-cancerous SUV scores. In a scenario where a colorectal mass of 5 centimeters, composed of high focal displaysia cells registering an SUV score of 30, is it reasonable to consider that such an elevated score could have been the result of a real 'war zone' which gobbled up the glucose as the medicinal amounts of daily nutrients, supplements, vitamins and minerals and modified diet were 'at war' with the abnormal cell development?
Would an SUV score in the significantly elevated range of say 30, indicate that there was significant enough cell growth/mutation taking place as to be measurable in a 2 month period?
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Reply # - December 17, 2014, 09:52 PM
A very high SUV like that
A very high SUV like that would be very likely to be from cancer, much less likely from some other cause, but a hypermetabolic (high SUV) spot on a PET scan still doesn't diagnose cancer. The critical test is a biopsy to check under a microscope what it actually represents.
Good luck.
-Dr. West
Reply # - December 18, 2014, 12:10 AM
What growth rate of the mass
What growth rate of the mass could be anticipated from a site registering an SUV of 30?
A tissue sample was taken during a colonoscopy 3 months ago....no cancer.....but there were cells with highly focused displasia. Cancer cells were assumed to be at the center of the mass....but no pathology to prove it or diagnose.
Size of mass has remained the same during this time period with the colonoscopy, CT and PET scan.
How does a bunch of pre-cancerous cells put up such a large SUV rate without growing in size?
By the way, I found this website today, and believe I have you to thank for its existence, Dr West. I am thankful and appreciative for its availability. I can see it is very beneficial to a broad spectrum of people and situations. Thank you for such a prompt response.....I am amazed:)
Reply # - December 18, 2014, 01:48 PM
Generally speaking the higher
Generally speaking the higher the suv value the more aggressive the cancer but there's most always room for other reasons. Unfortunately we don't have faculty with specialty in colorectal carcinoma meaning there may be intricacies our faculty aren't up to date on (our docs would prob know whether that's a valid concern).
I'm curious why you asked about a specialized diet. My imagination can come up with questions like that as well.
I understand the frustration of getting a dx from a wife's perspective. My husband's docs were 99% sure he had cancer. He had several undiagnosable biopsies ending with full out open surgery to diagnose. It's very unusual but with cancer anything can happen.
I hope you get answers, if not from your current team then from another.
Much luck,
Janine
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Reply # - December 18, 2014, 07:23 PM
I can't explain it. I doubt
I can't explain it. I doubt that pre-cancerous cells alone are able to generate that SUV, and just because that's all a biopsy shows doesn't mean that's all that is within the lesion. I cannot explain why it isn't growing, and I would say that the most important and direct way to understand what is actually happening. As Janine describes, you don't have to go far to find people who required several biopsies to obtain a final, definitive diagnosis. In some cases, if the lesion is ambiguous but worrisome enough, we end up removing the entire lesion in order to make a diagnosis and end the speculation.
Good luck.
-Dr. West