I have been in Xalkori for 2 months, A current CT scans shows the Stage 4 NSCLC (ROS1) is stable. An EKG shows a higher QTc (596) since the last EKG 4 months ago (450), Since the Xalkori may be affecting this would merely stopping the drug and waiting a week or two for a followup EKG be recommended or should I be more concerned?

Well, here we are, barring any last minute complications my wife should start the TAK-788 trial next week. She has already had her main blood work and a CT scan. All she needs now is an updated brain MRI and a blood test for magnesium and bilirubin.

This seems to be an option for everyone with brain metastases (inform your doctor as it is quite new) ) Here are links to research done in Spain in 2017 where patients brain mets improved significantly by taking silibinin :
https://academic.oup.com/annonc/article/28/suppl_5/mdx366.035/4108588 and https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5077992/

My mum (73years,IVstage,small meta in lymph nodes,EGFR+,exon18,G719X), was for 21 months on 1st line Afatinib (first 40% reduction, last three months with slow progression), after that she was on pemetrexed monotherapy for 3 months with quite significant progression (30%). Since finishing on Afatinib 3 liquid biopsies for T790M have been done with no outcome - not even the original mutation showed. Tissue biopsy would be problematic.

Is anyone on Tagrisso (osimertinib) taking or took dexamethasone? I want to start my mum on osimertinib, but she is taking dexamethasone for brain lesion edema. I learned there might be interaction between these two : dexamethasone may reduce the blood levels of osimertinib, which may make the medication less effective in some cases. Does anyone have any experience or recommendations and did you have good response from Tagrisso while on dexamethasone?