Dear Doctors and Moderators,

  I have been on tarceva for 9 months and after progression and high toxicity moved to Tagrisso. Blood biopsy showed same l858r mutation, but no t790m one. My question is: if I progressed on osimertinib but keeping same original mutation, can I try afatinib?  Or Tagrisso plus afatinib combo? Or Tagrisso plus avastin? Retry tarceva plus Tagrisso combo?

Thank you very much for your assistance.

❤️

Hi community,

I was diagnesed advanced, NSCLC, with egfr mutation in 11, 2016. Was on Tarceva for 18 nonths, Am currently on Tagrisso but I am no longer progression free.

Platinum boublet chemo + Avastin is an option for me, was wondering what others are doing in similar situation.  

Thanks

Hi,

Hello! My mom got her first dose of Tecentriq & Alimta 3 weeks ago. She seems to have developed massive swelling in the right foot that’s moving up her leg (no clots per ultrasound).  She also has a burning sensation in her mouth.  Her next Alimta + Tecentriq infusion is on 7/4.  Would love some thoughts on what might be going on. Thank you so much!

Well, here we are again, asking more questions....

So, as you might have inferred from a previous post, our oncologist is confering with his tumor board today on recommendations for my wife's next treatments, and we should hear back tomorrow.

Hi, I hope someone from this great community can help. My mom was diagnosed with Stage 4 NSCLC 3.5 years ago. At the time of diagnosis she tested positive for EGFR l858r and was subsequently put on Tarceva which lasted a little over a year before she progressed. Went on Tagrisso for about 1.5 years. She recently tried carbo/alimpta/Keytruda but discontinued in March this year since she was still progressing after 3 rounds.

Is it known to progress on tarceva to cancer related lymphangitis? Is there any specific treatment for this type of cancer or it treats with same targeted drugs?

Thank you for any advice.

Vera

My GGO was not resolved after been on antibiotic and 30 mg of prednisone for a week. I have cough and shortness of breath. My pulmonologist thinks about 3 reasons: tarceva toxicity, cancer related lymphangitis ( cancer cells blocking lymph vessels) or fungal bacretial infection.  Bronchoscopy cant be done because my condition with lack of oxygen. So the plan is to stop tarceva for 1-2 weeks and keep 40 mg of prednisone to see how it will affect my breathing . I really worry about this break.

Dear Doctors, could you please help me with the right treatment for newly detected mutation by blood biopsy. This is MET , exon 16, H1112R mutation in combination with my existing one which is exon 21, l858r. It has been reported that those two mutations exist in equal amounts. 

Is there any update on efficacy of osicent versus tagrix please? Cost is a issue and wanted to know if one is more effective than the other as erlotinib isnt working and lung cancer has widespread brain metastatis.any info will be valuable please.